Regulating Protective Immunity in Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Regulating protective immunity in atherosclerosis.
Atherosclerosis is a disease characterized by chronic inflammation. Looking back it is almost embarrassing how long it took for us to realize that the presence of these innate immune responses also was associated with activation of adaptive immunity. The first hints of an involvement of adaptive immunity in atherosclerosis came from studies performed by Göran Hansson and his coworkers about 20 ...
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recognition of lipid and glycolipid antigens by CD1d. The finding that CD1d-activating lipids may accumulate in hyperlipidemic subjects supports a role for NK T cells in bridging hyperlipidemia and inflammation [10] . Another immune cell, the Th17 cell producing IL-17, and its role in atherosclerosis has been much debated due to recent apparently conflicting data [11–13] . In the third article,...
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The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2005
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000159183.88730.79